ANALYSIS OF THE EFFECT OF RESISTANT EXERCISE ON IGF2 EXPRESSION IN C57BL/6 MICE WITH CACHEXIA ASSOCIATED WITH CANCER
DOI:
https://doi.org/10.46551/rn2022132000062Keywords:
Cutaneous melanoma, Cachexia, Weathered ExerciseAbstract
Introduction: Cutaneous melanoma is a tumor of neuroectodermal origin, covering the entire epidermis. The referred tumor has a high incidence and high mortality rate, therefore it is considered a very important skin cancer in medical investigation. Objective: To verify the effects of resistance exercise on IGF-2 expression in C57BL/6 mice with cachexia associated with the syngeneic tumor model of cutaneous melanoma. Methods: Experimental, analytical, prospective and quantitative approach. Twelve female C57BL/6 mice were used, inoculated with B16-F10 cells of the cutaneous melanoma lineage. Twelve female C57BL/6J mice were used, where they were randomly distributed into 3 groups. The first group was the control (n=4), which had not participated in any type of intervention, the second group being the control group with tumor induction (TUMOR) (n=4), which did not undergo any type of intervention and was induced to cancer-associated cachexia, the third group (TRTUMOR) (n=4) was climbing training, performing resistance exercise with shock stimulation and also being induced cancer-associated cachexia. Results: The inferential analysis of the study showed no significant difference. Effect size was rated as large (1.59) for the CONTROL vs TUMOR group; very large (2.43) CONTROL vs TRTUMOR and moderate (0.67) TUMOR vs TRTUMOR. Conclusion: The results show that there was a non-significant increase in the IGF-2 protein, however, there was expression of the protein in rats that practiced physical activity.
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