Vacuna antigénica de antígenos quiméricos contra la garrapata del ganado Rhipicephalus microplus: revisión integrativa
DOI:
https://doi.org/10.46551/ruc.v27n2a1Resumen
Objetivo: Investigar potenciales antígenos para vacunas quiméricas en el control de la garrapata bovina Rhipicephalus microplus. Métodos: El estudio se realizó con base en criterios del método PRISMA, con los descriptores: "Tick cattle and chimeric vaccine", términos en inglés, seleccionando artículos entre 2013 y 2023 recuperados de tres bases de datos: Web of Science, PubMed y Scopus. Resultados: La búsqueda resultó en la identificación de 15 artículos en la base de datos Web of Science, 10 en la base de datos Scopus y 12 en la base de datos PubMed, de los cuales la mayoría se duplicaron entre las bases de datos. Después de excluir los duplicados, se seleccionaron 7 artículos relevantes para el tema propuesto, 5 de los cuales eran exclusivos de Web of Science y 1 exclusivo de PubMed. Los métodos de construcción de vacunas investigaron antígenos potenciales para diferentes especies de garrapatas, incluidos cócteles de antígenos, fusiones de antígenos de múltiples especies (R. microplus, R. annulatus, Haemophysalis longicornis y R. haemophysaloides), combinaciones con epítopos de patógenos transmitidos, fusiones con proteínas de membrana y epítopos salivales, ADN, proteínas basadas en subolesinas y diversas estrategias de vacunación. Conclusión: Los estudios seleccionados destacan el potencial de las vacunas quiméricas para inducir respuestas inmunes más efectivas y duraderas en el control de garrapatas bovinas. Aunque se ha avanzado mucho, aún queda mucho camino por recorrer para obtener una vacuna eficaz para controlar la infestación de garrapatas.
Descargas
Citas
RODRIGUEZ-VIVAS, Roger et al. Estratégias para o controle de carrapatos Rhipicephalus microplus em um mundo de resistência acaricida convencional e lactona macrocíclica. Parasitology Research, v. 117, p. 3-29, 2017. https://doi.org/10.1007/s00436-017-5677-6
HURTADO, Oscar Jamer Betancourt; GIRALDO-RÍOS, Cristian. Economic and health impact of the ticks in production animals [Internet]. Ticks and Tick-Borne Pathogens. IntechOpen, 2019. Available from: http://dx.doi.org/10.5772/intechopen.81167
BOULANGER, Nathalie et al. Ticks and tick-borne diseases. Médicine et Maladies Infectieuses, v. 49, n. 2, p. 89-97, 2019. https://doi.org/10.1016/j.medmal.2019.01.007
CALVANO, Maria Paula Cavuto Abrão et al. Eficiência econômica do controle de Rhipicephalus microplus e efeito sobre o desempenho de bovinos de corte no Cerrado brasileiro. Experimental and Applied Acarology, v. 79, p. 459-471, 2019. https://doi.org/10.1007/s10493-019-00446-5
KASAIJA, Paul et al. Cattle ticks and tick-borne disease: a review of Uganda’s situation. Ticks and Tick-borne Diseases, v. 12, n. 5, 101756, 2021. https://doi.org/10.1016/j.ttbdis.2021.101756
LEW-TABOR, Alicja; VALLE, Manuel Rodriguez. A review of reverse vaccinology approaches for the development of vaccines against ticks and tick-borne diseases. Ticks and Tick-borne Diseases, v. 7, n. 4, p. 573-585, 2016. https://doi.org/10.1016/j.ttbdis.2015.12.012
STRYDOM, Tom et al. The economic impact of parasitism from nematodes, trematodes and ticks on beef cattle production. Animals, v. 13, 1599, 2023. https://doi.org/10.3390/ani13101599
SOUSA, Ana Beatriz Barbosa et al. First description of acaricide resistance in populations of Rhipicephalus microplus tick from the Lower Amazon, Brazil. Animals, v. 12, 2931, 2022. https://doi.org/10.3390/ani12212931
DE LA FUENTE, José; CONTRERAS, Marinela. Tick vaccines: current status and future directions. Expert Review of Vaccines, v. 14, p. 1367-1376, 2015. https://doi.org/10.1586/14760584.2015.1076339
NDAWULA-JÚNIOR, Charles; TABOR, Ala. Cocktail anti-tick vaccines: the unforeseen constraints and approaches toward enhanced efficacies. Vaccines, v. 8, n. 3, 457, 2020. https://doi.org/10.3390/vaccines8030457
SASAKI, Sérgio Daishi; TANAKA, Aparecida Sadae. rBmTI-6, a Kunitz-BPTI domain protease inhibitor from the tick Boophilus microplus, its cloning, expression and biochemical characterization. Veterinary Parasitology, v. 155, n. 1-2, p. 133-141, 2008. https://doi.org/10.1016/j.vetpar.2008.03.031
CANALES, Mário et al. Protective efficacy of bacterial membranes containing surface-exposed BM95 antigenic peptides for the control of cattle tick infestations. Vaccine, v. 27, n. 52, p. 7244-7248, 2009. https://doi.org/10.1016/j.vaccine.2009.09.123
PRUDENCIO, Carlos Roberto et al. Recombinant peptides as new immunogens for the control of the bovine tick, Rhipicephalus (Boophilus) microplus. Veterinary Parasitology, v. 172, n. 1-2, p. 122-131, 2010. https://doi.org/10.1016/j.vetpar.2010.04.012
DE LA FUENTE, José et al. Targeting arthropod subolesin/akirin for the development of a universal vaccine for control of vector infestations and pathogen transmission. Veterinary Parasitology, v. 181, n. 1, p. 17-22, 2011. https://doi.org/10.1016/j.vetpar.2011.04.018
CARREÓN, Diana et al. Vaccination with BM86, subolesin and akirin protective antigens for the control of tick infestations in white-tailed deer and red deer. Vaccine, v. 30, n. 2, p. 273-279, 2012. https://doi.org/10.1016/j.vaccine.2011.10.099
CONTRERAS, Marinela et al. Bacterial membranes enhance the immunogenicity and protective capacity of the surface-exposed tick Subolesin-Anaplasma marginale MSP1a chimeric antigen. Ticks and Tick-borne Diseases, v. 6, p. 820-828, 2015. http://dx.doi.org/10.1016/j.ttbdis.2015.07.010
XINNUO, Lei; XIONG, Cai; YI, Yang. Genetic engineering strategies for construction of multivalent chimeric VLPs vaccines. Expert Review of Vaccines, 2020. https://doi.org/10.1080/14760584.2020.1738227
CSORDAS, Bárbara Guimarães et al. Molecular characterization of the recombinant protein RmLTI-BmCG-LTB: Protective immunity against Rhipicephalus (Boophilus) microplus. PLoS ONE, v. 13, n. 2, e0191596, 2018. https://doi.org/10.1371/journal.pone.0191596
GALVÃO,Taís Freire; PANSANI, Thais de Souza Andrade. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA Statement. Epidemiologia e Serviços de Saúde, v. 24, n. 2, p. 335-342, 2015.
TORINA, Alvaro et al. Control of tick infestations and pathogen prevalence in cattle and sheep farms vaccinated with the recombinant Subolesin-Major Surface Protein 1a chimeric antigen. Parasites & Vectors, v. 7, 10, 2014. https://doi.org/10.1186/1756-3305-7-1
HASSAN, Ibrahim et al. Cross protection induced by combined Subolesin-based DNA and protein immunizations against adult Haemaphysalis longicornis. Vaccine, v. 38, p. 907-915, 2020. https://doi.org/10.1016/j.vaccine.2019.10.076
MAZUZ, Monica Lopes et al. Experimental infection of calves with transfected attenuated Babesia bovis expressing the Rhipicephalus microplus Bm86 antigen and eGFP marker: preliminary studies towards a dual anti-tick/Babesia vaccine. Pathogens, v. 10, 135, 2021. https://doi.org/10.3390/pathogens10020135
CONTRERAS, Marinela et al. Changes in serum biomarkers of oxidative stress in cattle vaccinated with tick recombinant antigens: a pilot study. Vaccines, v. 9, n. 5, 2021. https://dx.doi.org/10.3390/vaccines9010005
COSTA, Gabriel et al. A multiepitope chimeric antigen from Rhipicephalus microplus-secreted salivary proteins elicits anti-tick protective antibodies in rabbit. Veterinary Parasitology, v. 318, 109932, 2023. https://doi.org/10.1016/j.vetpar.2023.109932
ORTIZ, José Manuel Jaramillo et al. Immunisation of cattle against Babesia bovis combining a multi-epitope modified vaccinia Ankara virus and a recombinant protein induces strong Th1 cell responses but fails to trigger neutralising antibodies required for protection. Ticks and Tick-borne Diseases, v. 10, 101270, 2019. https://doi.org/10.1016/j.ttbdis.2019.101270
TABOR, Ala E. A review of Australian tick vaccine research. Vaccines, v. 9, 1030, 2021. https://doi.org/10.3390/vaccines9091030
DE LA FUENTE, José et al. Vaccination against ticks (Boophilus spp): the experience with Bm86-based vaccine Gavac™. Genetic Analysis: Biomolecular Engineering, v. 15, p. 143-148, 1999. https://doi.org/10.1016/S1050-3862(99)00018-2
MULENGA, Alberto; SUGIMOTO, Chihiro; ONUMA, Misao. Issues in tick vaccine development: identification and characterization of potential candidate vaccine antigens. Microbes and Infection, v. 2, n. 1, p. 1353-1361, 2000. https://doi.org/10.1016/S1286-4579(00)01289-2
PATARROYO, Joaquín et al. Bovine immunisation with a recombinant peptide derived from synthetic SBm7462® (Bm86 epitope construct) immunogen for Rhipicephalus microplus control. Ticks and Tick-borne Diseases, v. 11, 101461, 2020. https://doi.org/10.1016/j.ttbdis.2020.101461
SCOLES, Glen et al. Vaccination of cattle with synthetic peptides corresponding to predicted extracellular domains of Rhipicephalus (Boophilus) microplus aquaporin 2 reduced the number of ticks feeding to repletion. Parasites & Vectors, v. 15, 49, 2022. https://doi.org/10.1186/s13071-022-05166-1
GRISI, Laerte et al. Reassessment of the potential economic impact of cattle parasites in Brazil. Revista Brasileira de Parasitologia Veterinária, v. 23, p. 150-156, 2014. http://dx.doi.org/10.1590/S1984-29612014042
STEPANOVA, Lorenzo et al. Influence of the linking order of fragments of Ha2 and M2e of the influenza A virus to flagellin on the properties of recombinant proteins. Acta Naturae, v. 10, n. 1, p. 85-94, 2018. https://doi.org/10.32607/20758251-2018-10-1-85-94
