Chimeric vaccine antigens against the cattle tick Rhipicephalus microplus: Integrative review
DOI:
https://doi.org/10.46551/ruc.v27n2a1Abstract
ABSTRACT
Objective: To investigate potential antigens for chimeric vaccines in the control of the bovine tick Rhipicephalus microplus. Methods: The study was conducted based on criteria of the PRISMA method, with the descriptors: "Tick cattle and chimeric vaccine", terms in English, selecting articles between 2013 and 2023 retrieved from three databases: Web of Science, PubMed, and Scopus. Results: The search resulted in the identification of 15 articles in the Web of Science database, 10 in the Scopus database and 12 in the PubMed database, of which most were duplicated between the databases. After excluding duplicates, 7 articles relevant to the proposed theme were selected, 5 of which were exclusive to Web of Science and 1 exclusive to PubMed Vaccine construction methods investigated potential antigens for different tick species, including antigen cocktails, multi-species antigen fusions (R. microplus, R. annulatus, Haemophysalis longicornis, and R. haemophysaloides), combinations with transmitted pathogen epitopes, fusions with membrane proteins and salivary epitopes, DNA, subolesin-based proteins, and diverse vaccination strategies. Conclusion: The selected studies highlight the potential of chimeric vaccines to induce more effective and long-lasting immune responses in the control of cattle ticks. Although much progress has been made, there is still a long way to go to obtain an effective vaccine to control tick infestation.
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References
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