Antígenos quiméricos vacinais contra o carrapato bovino Rhipicephalus microplus: Revisão Integrativa
DOI:
https://doi.org/10.46551/ruc.v27n2a1Resumo
RESUMO
Objetivo: Investigar sobre antígenos potenciais para vacinas quiméricas no controle do carrapato bovino Rhipicephalus microplus. Métodos: O estudo foi conduzido com base em critérios do método PRISMA, com os descritores: “Tick cattle and chimeric vaccine”, termos em inglês, selecionando artigos entre 2013 e 2023 recuperados de três bases de dados: Web of Science, PubMed e Scopus. Resultados: A pesquisa resultou na identificação de 15 artigos na base Web of Science, 10 na base Scopus e 12 na base PubMed, dos quais a maioria estava em duplicidade entre as bases. Após a exclusão das duplicidades, foram selecionados 7 artigos relevantes para o tema proposto, sendo 5 exclusivos da Web of Science e 1 exclusivo da PubMed. Os métodos de construção de vacinas investigaram antígenos potenciais para diferentes espécies de carrapatos, incluindo coquetéis de antígenos, fusões de antígenos de várias espécies (R. microplus, R. annulatus, Haemophysalis longicornis e R. haemophysaloides), combinações com epítopos de patógenos transmitidos, fusões com proteínas de membrana e epítopos salivares, DNA, proteínas baseadas em subolesina e diversas estratégias de vacinação. Conclusão: Os estudos selecionados destacam o potencial das vacinas quiméricas para induzir respostas imunes mais eficazes e duradouras no controle de carrapatos bovinos. Embora muitos progressos tenham sido feitos, ainda há um longo caminho para se obter uma vacina eficaz no controle da infestação por carrapatos.
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