Complexos de reparo mismatch: mecanismos e funções

Autores

  • Marcos Vinícius Macedo de Oliveira Doutorando em Ciências da Saúde na UNIMONTES.
  • Carlos Alberto de Carvalho Fraga Doutorando em Ciências da Saúde na UNIMONTES.
  • André Luiz Sena Guimarães Pós-doutorado em Biologia Celular na University of Western Ontario. Professor da UNIMONTES.

Palavras-chave:

Reparo de DNA Mismatch. MutL. MutS. MSH2.

Resumo

As proteínas do Reparo de DNA Mismatch (MMR) são encontradas em diversos mecanismos importantes de funções celulares. A principal função dessas proteínas está relacionada ao reparo pós replicacional do
DNA, corrigindo as bases incorporadas incorretamente ao genoma devido ao erro de replicação. A perda das
funções das proteínas MMR é geralmente aumentada devido a mutações espontâneas em organismos, que vão
desde bactérias a humanos. As mutações nos genes MMR causam câncer colorretal hereditário não-poliposo,
e, a perda das funções dos genes MMR está associada com uma significativa fração de cânceres esporádicos.
Esta revisão busca resumir os principais mecanismos moleculares das funções protéicas dos MMR. O conhecimento acerca do mecanismo de reparo MMR está em processo de crescimento ao longo dos anos, embora a complexidade de suas vias de sinalização, ainda, permanece pouco conhecida. O entendimento desses
mecanismos, portanto, faz-se crucial para maior suporte no desenvolvimento de novos alvos terapêuticos para
doenças relacionadas a essa via de reparo.

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Publicado

2020-05-04

Como Citar

MACEDO DE OLIVEIRA, M. V. .; DE CARVALHO FRAGA, C. A. .; SENA GUIMARÃES, A. L. . Complexos de reparo mismatch: mecanismos e funções. Revista Unimontes Científica, [S. l.], v. 11, n. 1/2, p. 31–36, 2020. Disponível em: https://www.periodicos.unimontes.br/index.php/unicientifica/article/view/2273. Acesso em: 22 maio. 2024.

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