Transtorno do Espectro do Autismo: uma revisão sobre etiologia, epigenética e mutação de novo

Autores

  • Fernanda Alves Maia Universidade Estadual de Montes Claros - UNIMONTES
  • Maria Tereza Carvalho Almeida Universidade Estadual de Montes Claros - UNIMONTES
  • Victor Bruno da Silva Universidade Estadual de Montes Claros - UNIMONTES
  • Maria Rachel Alves
  • Marise Fagundes Silveira Universidade Federal de São Paulo - UNIFESP

Palavras-chave:

Transtorno Autístico; Mutação; Metilação; Revisão.

Resumo

A pessoa com o Transtorno do Espectro do Autismo (TEA) compartilha sintomas centrais no comprometimento de três áreas do neurodesenvolvimento: deficits de habilidades sociais, deficits de habilidades comunicativas e presença de comportamentos, interesses e/ou atividades restritos, repetitivos e estereotipados. O aumento na prevalência desse transtorno é preocupante e reforça a necessidade de se investigar os seus principais fatores de risco. Assim, o presente estudo teve como finalidade apresentar uma revisão da literatura a respeito do TEA, sua etiologia, aspectos epigenéticos e mutação de novo. Para o mapeamento deste estudo tomou-se como base bibliográfica a Base de Dados Pubmed. Os resultados apontam que o TEA é caracterizando como um transtorno de herança multifatorial e que fatores ambientais, independentes ou em conjunto com os fatores genéticos, aumentam o risco desse transtorno. Além disso, estudos moleculares têm destacado o papel das mutações de novo e da epigenética no desenvolvimento do TEA.

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Biografia do Autor

Maria Rachel Alves

Mestranda em Ciências da Educação pela Universidad Tecnológica International-UTIC

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Publicado

05-03-2020

Como Citar

Alves Maia, F. ., Tereza Carvalho Almeida, M., Bruno da Silva, V. ., Rachel Alves, M. ., & Fagundes Silveira, M. (2020). Transtorno do Espectro do Autismo: uma revisão sobre etiologia, epigenética e mutação de novo. Revista Renome, 6(1), 101–114. Recuperado de https://www.periodicos.unimontes.br/index.php/renome/article/view/1243

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