Exercício Físico Como Aliado Profilático Contra a COVID-19: Uma Hipótese Envolvendo o Receptor do Tipo Toll 7 (TLR-7)
Exercise as a prophylactic ally against covid-19: a hypothesis involving the Toll-Like Receptor 7
DOI:
https://doi.org/10.46551/ruc.v25n1a8Palavras-chave:
Exercício Físico, COVID-19, Imunidade Inata, SARS-CoV-2, TLR-7Resumo
Objetivo: Investigar a potencial relação entre o Receptor Toll-like 7 (TLR7) e o exercício físico na resposta imune contra a COVID-19. Método: Trata-se de uma revisão bibliográfica fundamentada por estudos originais em Língua Inglesa, indexados na base de dados PubMed e publicados entre 2006 e maio de 2022. Resultados: Evidências sugerem que o TLR7 é importante no processo imunológico inicial contra a COVID-19, pois é responsável no processo de ativação das células dendríticas plasmocitóides e produção de Interferons Tipo I (IFN-I), que estão relacionados à atenuação da gravidade da doença. Além disso, mutações de perda de função do TLR7 e a diminuição da resposta do IFN-I estão associadas ao agravamento da COVID-19. Embora nenhum estudo tenha avaliado diretamente a relação entre exercício físico e TLR7 em casos de COVID-19, evidências disponíveis sugerem que o exercício físico pode provocar alterações na expressão de TLR7, indicando um novo tema para investigação. Conclusões: Novos estudos são necessários para esclarecer os efeitos dos exercícios físicos sobre o TLR7 e seu potencial nas defesas antivirais contra a COVID-19, considerando especificidades como intensidade do exercício, modalidade do exercício, duração da sessão de treinamento ou programa de exercícios, população avaliada ou outras possíveis variáveis.
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