EFFECTS OF TRIBUTYLTIN EXPOSURE IN THE MALE MAMMAL’S REPRODUCTIVE SYSTEM: A SYSTEMATIC REVIEW

Autores

  • Lucília Silva Gontijo Universidade Federal Fluminense (UFF)
  • Tatiana Jales Moreira Universidade Federal Fluminense (UFF)
  • Nair Amélia Prates Barreto Universidade Federal de São Paulo (UNIFESP)
  • Enedina Gonçalves Almeida Universidade Estadual de Montes Claros (Unimontes)
  • Elisabeth Maróstica Universidade Federal Fluminense (UFF)

DOI:

https://doi.org/10.46551/ruc.v24n1a

Palavras-chave:

Tributyltin, Spermatogenesis, Sperm, Gametogenesis, Male reproductive system

Resumo

Objective: To conduct a systematic review of the literature describing male mammals' reproductive and sexual parameters exposed to the biocide TBT. Method: A formal computer-assisted search was performed independently by two authors using five online databases and keywords. A manual search of the reference list of the articles found for relevant original articles was also used. We initially identified potentially eligible publications related to the topic of interest through this procedure. The last systematic search resulted in adequate data on TBT toxicity in the mammalian male reproductive tract. Results: Decreases in testicular, epididymal, prostate and seminal vesicle weights were observed at higher TBT ranges. Decreases in serum testosterone levels were reported in some studies, with some histological changes in the surveyed tissues and decreased transcriptional expressions of steroidogenic enzymes. Notably, there were significant reductions in sperm count and motility and increased abnormalities. Conclusions: Further studies are needed to elucidate the precise manner of TBT's deleterious mechanisms of action on the spermatogenesis process. Therefore, a comprehensive survey of TBT levels in food and water sources should also be conducted better to protect susceptible populations from potentially deleterious reproduction effects.

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Biografia do Autor

Lucília Silva Gontijo, Universidade Federal Fluminense (UFF)

Mestre em Farmacologia Terapêutica e Experimental. Universidade Federal do Rio de Janeiro (UFRJ). Doutoranda em Fisiologia e Farmacologia. Universidade Federal Fluminense (UFF). Professora da Universidade Estadual de Montes Claros (Unimontes). Montes Claros - MG - Brasil. 

Tatiana Jales Moreira, Universidade Federal Fluminense (UFF)

Mestre em Ciências Biomédicas. Universidade Federal Fluminense (UFF). Niterói - RJ - Brasil.

Nair Amélia Prates Barreto, Universidade Federal de São Paulo (UNIFESP)

Mestre em Ensino em Ciências da Saúde. Universidade Federal de São Paulo (UNIFESP). Professora da Universidade Estadual de Montes Claros (Unimontes). Montes Claros - MG - Brasil. 

Enedina Gonçalves Almeida, Universidade Estadual de Montes Claros (Unimontes)

Graduada em Medicina. Fundação Norte Mineira de Ensino Superior. Especialista em Alergia Clínica. Sociedade Brasileira de Alergia e Imunopatologia (SBAI). Professora da Universidade Estadual de Montes Claros (Unimontes). Montes Claros - MG - Brasil.

Elisabeth Maróstica, Universidade Federal Fluminense (UFF)

Doutora em Farmacologia. Universidade Federal de São Paulo (UNIFESP). Professora da Universidade Federal Fluminense (UFF). Niterói - RJ - Brasil. 

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SILVA GONTIJO, L.; JALES MOREIRA, T.; AMÉLIA PRATES BARRETO, N.; GONÇALVES ALMEIDA, E.; MARÓSTICA, E. EFFECTS OF TRIBUTYLTIN EXPOSURE IN THE MALE MAMMAL’S REPRODUCTIVE SYSTEM: A SYSTEMATIC REVIEW. Revista Unimontes Científica, [S. l.], v. 24, n. 1, p. 1–25, 2022. DOI: 10.46551/ruc.v24n1a. Disponível em: https://www.periodicos.unimontes.br/index.php/unicientifica/article/view/5006. Acesso em: 26 set. 2022.

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