• Lucília Silva Gontijo Universidade Federal Fluminense (UFF)
  • Tatiana Jales Moreira Universidade Federal Fluminense (UFF)
  • Nair Amélia Prates Barreto Universidade Federal de São Paulo (UNIFESP)
  • Enedina Gonçalves Almeida Universidade Estadual de Montes Claros (Unimontes)
  • Elisabeth Maróstica Universidade Federal Fluminense (UFF)




Tributyltin, Spermatogenesis, Sperm, Gametogenesis, Male reproductive system


Objective: To conduct a systematic review of the literature describing male mammals' reproductive and sexual parameters exposed to the biocide TBT. Method: A formal computer-assisted search was performed independently by two authors using five online databases and keywords. A manual search of the reference list of the articles found for relevant original articles was also used. We initially identified potentially eligible publications related to the topic of interest through this procedure. The last systematic search resulted in adequate data on TBT toxicity in the mammalian male reproductive tract. Results: Decreases in testicular, epididymal, prostate and seminal vesicle weights were observed at higher TBT ranges. Decreases in serum testosterone levels were reported in some studies, with some histological changes in the surveyed tissues and decreased transcriptional expressions of steroidogenic enzymes. Notably, there were significant reductions in sperm count and motility and increased abnormalities. Conclusions: Further studies are needed to elucidate the precise manner of TBT's deleterious mechanisms of action on the spermatogenesis process. Therefore, a comprehensive survey of TBT levels in food and water sources should also be conducted better to protect susceptible populations from potentially deleterious reproduction effects.


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Biografia do Autor

Lucília Silva Gontijo, Universidade Federal Fluminense (UFF)

Mestre em Farmacologia Terapêutica e Experimental. Universidade Federal do Rio de Janeiro (UFRJ). Doutoranda em Fisiologia e Farmacologia. Universidade Federal Fluminense (UFF). Professora da Universidade Estadual de Montes Claros (Unimontes). Montes Claros - MG - Brasil. 

Tatiana Jales Moreira, Universidade Federal Fluminense (UFF)

Mestre em Ciências Biomédicas. Universidade Federal Fluminense (UFF). Niterói - RJ - Brasil.

Nair Amélia Prates Barreto, Universidade Federal de São Paulo (UNIFESP)

Mestre em Ensino em Ciências da Saúde. Universidade Federal de São Paulo (UNIFESP). Professora da Universidade Estadual de Montes Claros (Unimontes). Montes Claros - MG - Brasil. 

Enedina Gonçalves Almeida, Universidade Estadual de Montes Claros (Unimontes)

Graduada em Medicina. Fundação Norte Mineira de Ensino Superior. Especialista em Alergia Clínica. Sociedade Brasileira de Alergia e Imunopatologia (SBAI). Professora da Universidade Estadual de Montes Claros (Unimontes). Montes Claros - MG - Brasil.

Elisabeth Maróstica, Universidade Federal Fluminense (UFF)

Doutora em Farmacologia. Universidade Federal de São Paulo (UNIFESP). Professora da Universidade Federal Fluminense (UFF). Niterói - RJ - Brasil. 


ELLIS, Derek; PATTISINA Agan Limy. Widespread neogastropod imposex: A biological indicator of global TBT contamination? Marine Pollution Bulletin, v. 21, n. 5, p. 248-253, 1990.

MILLER, M. E.; COONEY, Joseph J. Effects of Tri-, Di- and monobutyltin on heterotrophic nitrifying bacteria from surficial estuarine sediments. Archives of Environmental Contamination and Toxicology, v. 27, n. 4, p. 501-506, 1994.

RONIS, Martin.; MASON, Andrew Zed. The metabolism of testosterone by the periwinkle (Littorina littorea) in vitro and in vivo: Effects of tributyl tin. Marine Environmental Research. v. 42, n. 1-4, p. 161-166, 1996.

ADEEKO, Adedayo et al. Effects of in utero tributyltin chloride exposure in the rat on pregnancy outcome. Toxicological Sciences, v. 74, n. 2, p. 407-415, 2003.

KANNAN Kurunthachalam.; FALANDYSZ, Jerzy. Butyltin residues in sediment, fish, fish-eating birds, harbour porpoise and human tissues from the Polish coast of the Baltic Sea. Marine Pollution Bulletin, v. 34, n. 3, p. 203-207, 1997.

WHALEN, Margaret M.; LOGANATHAN, Bommanna G.; KANNAN, Kurunthachalam. Immunotoxicity of environmentally relevant concentrations of butyltins on human natural killer cells in vitro. Environmental Research, v. 81, n. 2, p. 108-116, 1999.

KANNAN, Kurunthachalam.; SENTHILKUMAR, Kurunthachalam.; GIESY John. Occurrence of butyltin compounds in human blood. Environmental Science & Technology, v. 33, n. 10, p. 1776-1779, 1999.

ALUOCH, Aloice.; ODMAN-GHAZI, Sabah.; WHALEN, Margaret M. Pattern of MAP kinases p44/42 and JNK activation by non-lethal doses of tributyltin in human natural killer cells. Archives of Toxicology, v. 81, n. 4, p. 271-277, 2007.

ANTIZAR-LADISLAO, Blanca. Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. A review. Environment International, v. 34, n. 2, p. 292-308, 2008.

CAO, Dandan et al. Organotin pollution in China: an overview of the current state and potential health risk. Journal of Environmental Management, v. 90 Suppl 1, p. S16-24, 2009.

MATTHIESSEN, Peter.; GIBBS, Peter E. Critical appraisal of the evidence for tributyltin-mediated endocrine disruption in mollusks. Environmental Toxicology and Chemistry, v. 17, n. 1. p. 37-43, 1998.

FENT, Karl. Ecotoxicology of Organotin Compounds. Critical Reviews in Toxicology, v. 26, n. 3, p. 1-117, 1996.

EVANS, Stewart M.; BIRCHENOUGH, Andrew C.; BRANCATO, Mary Sue. The TBT Ban: Out of the Frying Pan into the Fire? Marine Pollution Bulletin, v. 40, n. 3, p. 204-211, 2000.

SUZDALEV, Suzdalev.; GULBINSKAS, Saulius.; BLAZAUSKAS, Nerijus. Distribution of tributyltin in surface sediments from transitional marine-lagoon system of the south-eastern Baltic Sea, Lithuania. Environmental Science and Pollution Research, v. 22, n. 4, p. 2634-2642, 2015.

ZEIDAN, Gabriela Calvi.; BOEHS, G. Assessment of tributyltin contamination based on imposex in Stramonita rustica (Mollusca: Gastropoda) along southern Bahia coast, northeastern Brazil. Brazilian Journal of Biology, v. 77, n. 1, p. 185-190, 2017.

INOUE, Suguru et al. Tributyltin contamination of bivalves in coastal areas around northern Kyushu, Japan. Environmental Toxicology, v. 21, n. 3, p. 244-249, 2006.

MITRA, Sumonto et al. Consequences of tributyltin chloride induced stress in Leydig cells: an ex-vivo approach. Environmental Toxicology and Pharmacology, v. 37, n. 2, p. 850-860, 2014.

FENT, Karl.; MUELLER, Markus D. Occurrence of organotins in municipal wastewater and sewage sludge and behavior in treatment plant. Environmental Science & Technology, v. 25, n. 3, p. 489-493, 1991.

CRISP, Thomas et al. Environmental endocrine disruption: an effects assessment and analysis. Environmental Health Perspectives, v. 106, Suppl 1, p. 11-56, 1998.

OBERDORSTER, Eva.; CHEEK, Ann Oliver. Gender benders at the beach: endocrine disruption in marine and estuarine organisms. Environmental Toxicology and Chemistry, v. 20, n. 1, p. 23-36, 2000.

NAKANISHI, Tsuyoshi. Endocrine disruption induced by organotin compounds; organotins function as a powerful agonist for nuclear receptors rather than an aromatase inhibitor. The Journal of Toxicological Sciences, v. 33, n. 3, p. 269-276, 2008.

ZHANG, Jiliang et al. Effect of tributyltin on testicular development in Sebastiscus marmoratus and the mechanism involved. Environmental Toxicology and Chemistry, v. 28, n. 7, p. 1528-1535, 2009.

YAN, Feihuan et al. Effects of tributyltin on epididymal function and sperm maturation in mice. Environmental Toxicology and Pharmacology, v. 28, n. 1, p. 19-24, 2009.

KANIMOZHI, Veerasamy et al. Apolipoprotein e Induction in Syrian Hamster Testis Following Tributyltin Exposure: A Potential Mechanism of Male Infertility. Reproductive Sciences, v. 21, n. 8, p. 1006-1014, 2014.

SHARPE, Richard. Hormones and testis development and the possible adverse effects of environmental chemicals. Toxicology Letters, v. 120, n. 1-3, p. 221-232, 2001.

NISHIKAWA, Jun-Ichi et al. Involvement of the retinoid X receptor in the development of imposex caused by organotins in gastropods. Environmental Science & Technology, v. 38, n. 23, p. 6271-6276, 2004.

ZHANG, Jiliang et al. Inhibition of thyroidal status related to depression of testicular development in Sebastiscus marmoratus exposed to tributyltin. Aquatic Toxicology, v. 94, n. 1, p. 62-67, 2009.

SMITH, Blakeman. Sexuality in the american mud snail, Nassarius obsoletus say. Journal of Molluscan Studies, v. 39, n. 5, p. 377-378, 1971.

WALDOCK, Michael.; WAITE, M.; THAIN, John E. Inputs of tbt to the marine environment from shipping activity in the U.K. Environmental Technology Letters, v. 9, n. 9, p. 999-1010, 1988.

PRIME, Mark et al. The occurrence of imposex in Hexaplex trunculus from the Croatian Adriatic. Marine Pollution Bulletin, v. 52, n. 7, p. 810-812, 2006.

TITLEY-O'NEAL, Cassander et al. The effects of organotin on female gastropods. Journal of Environmental Monitoring, v. 13, n. 9, p. 2360-2388, 2011.

GROTE, Konstanze et al. Effects of organotin compounds on pubertal male rats. Toxicology, v. 202, n. 3, p. 145-158, 2004.

WU, Xiaolong et al. A Short-Term Exposure to Tributyltin Blocks Leydig Cell Regeneration in the Adult Rat Testis. Frontiers in Pharmacology, v. 8, p. 704, 2017.

YU, Wook-joon et al. Effects of tributyltin chloride on the reproductive system in pubertal male rats. Journal of Veterinary Science, v. 4, n. 1, p. 29-34, 2003.

MAKITA, Yuji et al. Effects of Concurrent Exposure to Tributyltin and1,1-Dichloro-2,2 bis (p-chlorophenyl) ethylene (p,pø-DDE) on Immature Male Wistar Rats. Basic Clinical Pharmacology Toxicology, v. 97, n. 6, p. 364-368, 2005.

KIM, Suel-Kee et al. Inhibitory effect of tributyltin on expression of steroidogenic enzymes in mouse testis. International Journal of Toxicology, v. 27, n. 2, p. 175-182, 2008.

KANIMOZHI, Veerasamy et al. Molecular mechanisms of tributyltin-induced alterations in cholesterol homeostasis and steroidogenesis in hamster testis: In vivo and in vitro studies. Journal of Cellular Biochemistry, v. 119, n. 5, p. 4021-4037, 2017.

CHEN, Yufang et al. Reduction of spermatogenesis in mice after tributyltin administration. Toxicology, v. 251, n. 1-3, p. 21-27, 2008.

OMURA, Minoru et al. Two-generation reproductive toxicity study of tributyltin chloride in male rats. Toxicological Sciences, v. 64, n. 2, p. 224-232, 2001.

NAKAJIMA, Yonako et al. Organotin Compounds Suppress Testosterone Production in Leydig Cells from Neonatal Pig Testes. Journal of Health Science, v. 49, n. 6, p. 514-519, 2003.

MITRA, Sumonto.; SRIVASTAVA, Ankit.; KHANDELWAL, Shashi. Long term impact of the endocrine disruptor tributyltin on male fertility following a single acute exposure. Environmental Toxicology, v. 32, n. 10, p. 2295-2304, 2017.

YAN, Xueting et al. Organotin exposure stimulates steroidogenesis in H295R Cell via Camp pathway. Ecotoxicology and Environmental Safety, v. 156, p. 148-153, 2018.

YU, Wook Joon et al. Spermatogenetic disorders in adult rats exposed to tributyltin chloride during puberty. Journal of Veterinary Medical Science, v. 65, n. 12, p. 1331-1335, 2003.

KUMASAKA, Kenichi et al. Toxicity of the tributyltin compound on the testis in premature mice. Journal of Reproduction and Development, v. 48, n. 6, p. 591-597, 2002.

AITKEN, John.; KOOPMAN; Peter.; LEWIS, Sheena. Seeds of concern. Nature, v. 432, p. 48-52, 2004.

NAKAJIMA Yonako et al. Tributyltin chloride suppresses the P450c17 transcription involved in testosterone production induced by gonadotropin stimulation in cultured pig Leydig cells. Environmental Toxicology and Pharmacology, v. 20, n. 1, p. 11-17, 2005.

EBDON et al. The accumulation of organotins in adult and seed oysters from selected estuaries prior to the introduction of U.K. regulations governing the use of tributyltin-based antifouling paints. The Science of the Total Environment, v. 83, n. 1-2, p. 63-84, 1989.

TSUNODA Masashi. Simultaneous determination of organotin compounds in fish and shellfish by gas chromatography with a flame photometric detector. Tohoku Journal of Experimental Medicine, v. 169, p. 167-178, 1993.

SHIM W et al. Accumulation of tributyl- and triphenyltin compounds in Pacific oyster, Crassostrea gigas, from the Chinhae Bay System, Korea. Archives of environmental contamination and toxicology, v. 35, n. 1, p. 41-47, 1998.

HARINO H et al. Accumulation of butyltin and phenyltin compounds in various fish species. Archives of environmental contamination and toxicology, v. 39, n. 1, p. 13-19, 2000.

PENNINKS Andre. The evaluation of data-derived safety factors for bis(tri-n-butyltin)oxide. Food Additives & Contaminants, v.10, n. 3, p. 351-361, 1993.

MCALLISTER, Brian.; KIME, David. Early life exposure to environmental levels of the aromatase inhibitor tributyltin causes masculinisation and irreversible sperm damage in zebrafish (Danio rerio). Aquatic Toxicology, v. 65, n. 3, p. 309-316, 2004.

KANNAN Kurunthachalam.; FALANDYSZ Jerzy. Butyltin residues in sediment, fish, fish-eating birds, harbour porpoise and human tissues from the Polish coast of the Baltic Sea. Marine Pollution Bulletin, v. 34, n. 3, p. 204-207, 1997.

TAKAHASHI Shin et al. Butyltin residues in livers of humans and wild terrestrial mammals and in plastic products. Environmental Pollution, v. 106, n. 2, p. 213-218, 1999.

SANOCKA Dorota.; KURPISZ Maciej. Infertility in Poland–present status, reasons and prognosis as a reflection of Central and Eastern Europe problems with reproduction. Medical Science Monitor, v. 9, n. 3, p. SR16–20, 2003.

BABLOK Leszek et al. Patterns of infertility in Poland - multicenter study. Neuro Endocrinol Lett, v. 32, n. 6, p. 799-804, 2011.

KANNAN Kurunthachalam.; SENTHILKUMAR Kurunthachalam.; GIESY John. Occurrence of butyltin compounds in human blood. Environmental Science and Technology, v. 33, n. 10, p. 1776-1779, 1999.

MARTINEZ Gladys.; DANIELS Kimberly.; CHANDRA Anjani. Fertility of men and women aged 15-44 years in the United States: National Survey of Family Growth, 2006-2010. National Health Statistics Report, v. 12, n. 51, p. 1-28, 2012.

AGARWAL Ashok et al. A unique view on male infertility around the globe. Reproductive Biology and Endocrinology, v. 13, p. 37, 2015.

KANNAN Kurunthachalam et al. Butyltins in muscle and liver of fish collected from certain Asian and Oceanian countries. Environmental Pollution, v. 90, n. 3 p. 79-290, 1995.

MCLACHLAN Robert.; KRETSER David. Male infertility: the case for continued research. The Medical journal of Australia, v. 174, n. 3, p. 116-117, 2001.

HAUBRUGE Eric.; PETIT Fabian.; GAGE Matthew. Reduced sperm counts in guppies (Poecilia reticulata) following exposure to low levels of tributyltin and bisphenol A. Proceedings of the Royal Society B: Biological Sciences, v. 267, n. 1459, p. 2333-2337, 2000.

HELLMAN Leon et al. The effect of flutamide on testosterone metabolism and the plasma levels of androgens and gonadotropins. The Journal of Clinical Endocrinology & Metabolism, v 45, n. 6, p. 1224-1229, 1977.

OGATA, Tsutomu et al. Turner Syndrome and Xp Deletions: Clinical and Molecular Studies in 47 Patients. The Journal of Clinical Endocrinology & Metabolism, v. 86, n. 11, p. 5498-5508, 2001.

KATOH, Chiaki et al. Assessment of quantitative dual-parameter flow cytometric analysis evaluation of testicular toxicity using cyclophosphamide- and ethinylestradiol-treated rats. The Journal of Toxicological Sciences, v. 27, n. 2, p. 87-96, 2002.

ASHBY, John.; LEFEVRE, Paul. The Weanling Male Rat as an Assay for Endocrine Disruption: Preliminary Observations. Regulatory Toxicology and Pharmacology, v. 26, n. 3, p. 330-337, 1997.

SHETTY, Gunapala et al. Effect of long-term treatment with aromatase inhibitor on testicular function of adult male bonnet monkeys (M. radiata). Steroids, v. 63, n. 7-8, p. 414-420, 1998.

ROBERTSON, Kirsten et al. Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene. Proceedings of the National Academy of Sciences, v. 96, n. 14, p. 7986-7991, 1999.

FREITAG, Johannes; DÖCKE, Friedemann. Differential effects of chronic testosterone treatment on the onset of puberty in male rats. Experimental and Clinical Endocrinology & Diabetes, v. 90, n. 3, p. 361-364, 1987.

O’CONNOR, John et al. An ongoing validation of a tier I screening battery for detecting endocrine-active compounds (EACs). Toxicological Sciences, v. 46, n. 1, p. 45-60, 1998.

DOERING, Dagmar et al. Effects of butyltins on human 5alpha-reductase type 1 and type 2 activity. Steroids, v. 67, n.10, p. 859-867, 2002.

COOKE, Gerard. Effect of organotins on human aromatase activity in vitro. Toxicology Letters, v. 126, n. 2, p. 121-130, 2000.

LIU, Yi-Xun. Control of spermatogenesis in primate and prospect of male contraception. Archives of Andrology, v. 51, n. 2, p. 77-92, 2005.

PARK, Susan.; JAMESON, Larry. Minireview: transcriptional regulation of gonadal development and differentiation. Endocrinology, v. 146, n. 3, p. 1035-1042, 2005.

COUROT, Michel. Hormonal regulation of male reproduction (with reference to infertility in man). Andrologia, v. 8, n. 3, p. 187-193, 1976.

FRANCHIMONT, Paul. Regulation of gonadal androgen secretion. Hormone Research, v. 18, n. 1-3, p. 7-17, 1983.

TAN, Karen et al. The role of androgens in Sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor. Endocrinology, v. 146, n. 6, p. 2674-2683, 2005.

HOLDCRAFT, Robert.; BRAUN, Robert. Androgen receptor function is required in Sertoli cells for the terminal differentiation of haploid spermatids. Development, v. 131, n. 2, p. 459-467, 2004.

SHARPE, Richard et al. Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood. Reproduction, v. 125, n. 6, p. 769-784, 2003.

LEE, Victor et al. Variations in serum FSH, LH and testosterone levels in male rats from birth to sexual maturity. Reproduction, v. 42, n.1, p. 121-126, 1975.

KETELSLEGERS, Jean Marie et al. Developmental changes in testicular gonadotropin receptors: plasma gonadotropins and plasma testosterone in the rat. Endocrinology, v. 103, n. 1, p. 212-222, 1978.

MATSUMOTO, Alvin et al. Evidence for activation of the central nervous system-pituitary mechanism for gonadotropin secretion at the time of puberty in the male rat. Endocrinology, v. 119, n. 1, p. 362-369, 1986.

OJEDA, Sergio.; URBANSKI, Michael. Puberty in the rat. In: Knobil, E., Neill, J.D. (Eds.), The Physiology of Reproduction, 2 ed. Raven Press, New York, 1994.

GRAY, Leon Earl et al. Methoxychlor induces estrogen-like alterations of behavior and the reproductive tract in the female rat and hamster: effects on sex behavior, runnung wheel activity, and uterine morphology. Toxicology and Applied Pharmacology, v. 96, n. 3, p. 525-240, 1988.

MONOSSON, Emily et al. Peripubertal exposure to the antiandrogenic fungicide, vinclozolin, delays puberty, inhibits the development of androgen-dependent tissues, and alters androgen receptor function in the male rat. Toxicology and Industrial Health, v. 15, n. 1-2, p. 65-79, 1999.

KELCE, William et al. Persistent DDT metabolite p,p-DDe is a potent androgen receptor antagonist. Nature, v. 375, n. 6532, p. 581-585, 1995.

SUZUKI, Masatoshi.; NISHIAHARA, Masugi. Granulin precursor gene: a sex-steroid-induclible gene involved in sexual differentiation of the rat brain. Molecular Genetics and Metabolism, v. 75, n. 1, p. 31-37, 2002.

LEUNG, Posing et al. Androgen dependent expression of AT1 receptor and its regulation of anion secretion in rat epididymis. Cell Biology International, v. 26, n. 1, p. 117-122, 2002.

EWING, Larry.; ZIRKIN, Barry. Leydig cell structure and steroidogenic function. Laurentian Hormone Conference, v. 39, p. 599-635, 1983.

PAYNE, Anita.; YOUNGBLOOD. Geri. Regulation of expression of steroidogenic enzymes in Leydig cells. Biology of Reproduction, v. 52, n. 2, p. 217-225, 1995.

BERNAL-MANAS Carmen et al. Proliferation and apoptosis of spermatogonia in postpuberal boar (Sus domesticus) testes with spontaneous unilateral and bilateral abdominal cryptorchidism. Acta Histochemica, v. 107, n. 5, p. 365-372, 2005.

SCHLATT, Stefan.; WEINBAUER, Gerhard. Immunohistochemical localization of proliferating cell nuclear antigen as a tool to study cell proliferation in rodent and primate testes. International Journal of Andrology, v. 17, n. 4, p. 214-222, 1994.

SALAMA, Nader et al. Proliferating cell nuclear antigen in testes of infertile men with varicocelepreliminary results of interrelationship with sperm count before and after varicocelectomy. Scandinavian Journal of Urology and Nephrology, v. 37, n. 1, p. 48-52, 2003.

TANAKA, Hiroshi.; FUJISAWA, Masato.; OKADA, Hiroshi. Assessment of germ cell kinetics in the testes of patients with varicocele using image analysis of immunostained PCNA. BJU International, v. 78, n. 5, p. 769-771, 1996.

KISHTA, Osama et al. In utero exposure to tributyltin chloride differentially alters male and female Reproductive Toxicology, v. 23, n. 1, p. 1-11, 2006.

SYNG-AI, Christine.; BASU-BAUL, Tushar.; CHATTERJEE, Anupam. Antiproliferative and cytotoxic effect of a novel organotin compound on mammalian cells both in vitro and in vivo. Toxicology and Environmental Mutagenesis, v. 513, n. 1-2, p. 49-59, 2002.

AL-IMARA, Lamy et al. Inhibition of mouse spleen cell activity by organotin compounds: effect of attachment to a maltose residue to the organotin group. International Journal of Immunopharmacology, v.15, n. 3, p. 287-291, 1993.

DE SANTIAGO, Angelina.; AGUILAR-SANTELISES, Miguel. Organotin compounds decrease in vitro survival, proliferation and differentiation of normal human B lymphocytes. Human & Experimental Toxicology, v. 18, n. 10, p. 619-624, 1999.

JURKIEWICZ, Magdalena et al. Involvement of mitochondrial and death receptor pathways in tributyltin-induced apoptosis in rat hepatocytes. Biochimica et Biophysica Acta, v. 1693, n. 1, p. 15-27, 2004.

LEE, Jeongwu et al. The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology, v. 138, n. 5, p. 2081-2088, 1997.

HIKIM, Amiya Sinha et al. Deciphering the pathways of germ cell apoptosis in the testis. The Journal of Steroid Biochemistry and Molecular Biology, v. 85, n. 2-5, p.175-182, 2003.

RURANGWA, Eugène et al. Effect of tributyltin on adenylate content and enzyme activities of teleost sperm: a biochemical approach to study the mechanisms of toxicant reduced spermatozoa motility. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, v. 131, n. 3, p. 335-344, 2002.

DONNELLY, G et al. Direct effect of alcohol on the motility and morphology of human spermatozoa. Andrologia, v. 31, n. 1, p. 43-47, 1999.

THOMAS, M J.; THOMAS, J A. Toxic responses of the reproductive system. In: Klaassen, C.D. (Ed.), Casarett and Doull’s Toxicology. The Basic Science of Poisons, 6th ed. McGraw-Hill Companies Inc., New York, p. 673-709. 2001.




Como Citar

SILVA GONTIJO, L.; JALES MOREIRA, T.; AMÉLIA PRATES BARRETO, N.; GONÇALVES ALMEIDA, E.; MARÓSTICA, E. EFFECTS OF TRIBUTYLTIN EXPOSURE IN THE MALE MAMMAL’S REPRODUCTIVE SYSTEM: A SYSTEMATIC REVIEW. Revista Unimontes Científica, [S. l.], v. 24, n. 1, p. 1–25, 2022. DOI: 10.46551/ruc.v24n1a. Disponível em: https://www.periodicos.unimontes.br/index.php/unicientifica/article/view/5006. Acesso em: 13 ago. 2022.



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