SUSCETIBILIDADE ANTIFÚNGICA DE LEVEDURAS DO GÊNERO Malassezia
Palavras-chave:
Malassezia, Suscetibilidade Antifúngica, Agentes Antifúngicos, Resistencia Fúngica aos AntibióticosResumo
As leveduras do gênero Malassezia estão presentes na microbiota de animais homeotérmicos, são comensais da pele, mas também são associadas a doenças. Nesse sentido, o objetivo desse estudo é analisar a produção científica sobre suscetibilidade a antifúngicos comerciais de espécies de leveduras do gênero Malassezia isoladas em humanos. Trata-se de uma revisão integrativa, com buscas nas bases BDENF, MEDLINE, LILACS, Scopus e Web of Science por meio dos termos Malassezia e antifungal susceptibility. Dos 164 artigos regatados, 13 foram incluídos. Os estudos mostram que os compostos azólicos apresentam melhores desempenhos nos testes de suscetibilidade antifúngica, enquanto a anfotericna B é o fármaco que mais mostrou resultados desfavoráveis, assim como as equinocanidinas. A ausência de padronização das condições apropriadas para realização dos testes de suscetibilidade é apontada como um fator que interfere negativamente nos testes. Logo, pondera-se que a limitação de informações justifica a necessidade de adequações nos testes sensibilidade antimicrobiana.
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Referências
1- Dupuy AK, David MS, Li L, Heider TN, Peterson JD, Montano EA, et al. Redefining the Human Oral Mycobiome with Improved Practices in Amplicon-based Taxonomy: Discovery of Malassezia as a Prominent Commensal. Plos One. 2014 mar;9(3):e90899. Doi: https://doi.org/10.1371/journal.pone.0090899.
2- Theelen B, Carfacharia C, Gaitanis G, Bassukas ID, Boekhout T, Dawson TL. Malassezia ecology, pathophysiology, and treatment. Med mycol [internet]. 2018 apr [cited 2018 mai 30];56:S10–S25. Available from: https://academic.oup.com/mmy/issue/56/suppl_1.
3- Wu G, Zhao H, Li C, Rajapakse MP, Wong WC, J Xu J, et al. Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin. Plos Genetics. 2015 nov;11(11):e1005614. https://doi.org/10.1371/journal.pgen.1005614.
4- Cabañes FJ. Malassezia Yeasts: How Many Species Infect Humans and Animals? PLoS Pathog. 2014 feb;10(2):e1003892. Doi: http://doi.org/10.1371/journal.ppat.1003892
5- Kistowska M, Fenini G, Jankovic D, Feldmeyer L, Kerl K, Bosshard P. Malassezia yeasts activate the NLRP3 inflammasome in antigen-presenting cells via Syk-kinase signalling. Exp dermatol. 2014 dec;23(12):884–889. Doi: https://doi.org/10.1111/exd.12552
6- Velegraki A, Cafarchia C, Gaitanis G, Iatta R, Boekhout T. Malassezia Infections in Humans and Animals: Pathophysiology, Detection, and Treatment. PLoS Pathog. 2015 jan;11 (1):e1004523. Doi: https://doi.org/10.1371/journal.ppat.1004523
7- Gaitanis G, Velegraki A, Magiatis P, Pappas P, Bassukas ID. Could Malassezia yeasts be implicated in skin carcinogenesis through the production of aryl-hydrocarbon receptor ligands? Hipóteses Med [internet]. 2011 jul [cited 2018 mar 25];77(1):47-51. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(11)00122-8.
8- Hald M, Maiken AC, Else SL, Rune L, Erik FK, Saunte, DML. Evidence-based Danish Guidelines for the Treatment of Malassezia-related Skin Diseases. Acta Derm Venereol [Internet]. 2015 jan [cited 2018 mai 30];95(1):12-9. Available from: https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-1825.
9- Lorch JM, Palmer JM, Vanderwolf KJ, Schmidt KZ, Verant ML, Weller TJ, Blehert DS. Malassezia vespertilionis sp. nov.: a new cold-tolerant species of yeast isolated from bats. Persoonia [internet]. 2018 feb [cited 2018 mar 30];41:56–70. Available from: http://repository.naturalis.nl/document/654583.
10- Thayikkannu AB, Kindo AJ, Veeraraghavan M. Fungal prophylaxis in neonates: a review article. Adv neonatal care [Internet]. 2014 feb [cited 2017 dec 31];14(1):17-23. Available from: http://www-periodicos-capes-gov-br.ez9.periodicos.capes.gov.br/.
11- Ruiz LS, Pereira VBR. Importância dos fungos no ambiente hospitalar. Bol Inst Adolfo Lutz [Internet]. 2016 jan-dez [cited 2018 mar 30];2016 26(U): art.2. Available from: http://www.ial.sp.gov.br/resources/insituto-adolfolutz/publicacoes/bial/bial_26/26u_art-2.pdf.
12- Mendes KDS, Silveira RCCP, Galvão CM. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & contexto enferm [Internet]. 2008 dec [cited 2018 May 29];17(4):758-764. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-07072008000400018&lng=en
13- Ercole FF, Melo LS, Alcoforado CLGC. Integrative Review versus Systematic Review. Rev Min Enferm [Internet]. 2014 jan/mar [cited 2018 May 29];18(1):1-260. Available from: http://www.reme.org.br/artigo/detalhes/904
14- Silva DP, Nunes JBB, Moreira RTF, Costa LC. Primeiros socorros: objeto de educação em saúde para professors. Rev enferm UFPE on line [Internet]. 2018 mai [cited 2018 May 29];12(5):1444-53. Available from: https://periodicos.ufpe.br/revistas/revistaenfermagem/article/viewFile/234592/28912.
15- Souza MT, Silva MD, Carvalho R. Integrative review: what is it? How to do it? Einstein [Internet]. 2010 jan [cited 2018 May 29]8(11):102-6. Available from: http://www.scielo.br/pdf/eins/v8n1/1679-4508-eins-8-1-0102.pdf.
16- Galvis-Marína JC, Rodríguez-Bocanegraa MX, Pulido-Villa AP, Castañeda-Salazara MR, Celis-Ramírezb AM, Linares-Linares MY. Actividad antifúngica in vitro de azoles y anfotericina B frente a Malassezia furfur por el método de microdilución M27-A3 del CLSI y Etest®. Rer iberoam micol [Internet]. 2017 april–june [cited 2018 May 29];34:89-93. Available from: https://www.sciencedirect.com/science/article/pii/S1130140616300560.
17- Al-Sweih N, Ahmad S, Joseph L, Khan S, Khan Z. Malassezia pachydermatis fungemia in a preterm neonate resistant to fluconazole and flucytosine. Med Mycol Case Rep [Internet]. 2014 mai [cited 2018 May 29];5:9-11. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24936403.
18- Rojas FD, Sosa MDLA, Fernández MS, Cattana ME, Córdoba SB, Giusiano GE. Antifungal susceptibility of Malassezia furfur, Malassezia sympodialis, and Malassezia globosa to azole drugs and amphotericin B evaluated using a broth microdilution method. Sabouraudia [Internet]. 2014 aug [cited 2018 May 29];52(6), 641-646. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24965946.
19- Iatta R, Immediato D, Montagna MT, Otranto D, Cafarchia C. In vitro activity of two amphotericin B formulations against Malassezia furfur strains recovered from patients with bloodstream infections. Med Mycol [Internet]. 2015 apr [cited 2018 May 31];53(3):269-74. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25631480.
20- Rojas FD, Córdoba SN, Sosa MLA, Zalazar LC, Fernández MS, Cattana ME. Antifungal susceptibility testing of Malassezia yeast: comparison of two different methodologies. Mycosis. 2016 sept;60(2):104-111. Doi: https://doi.org/10.1111/myc.12556.
21- Leong C, Buttafuoco U, Glatz H, Bosshard PP. Antifungal Susceptibility Testing of Malassezia spp. with an Optimized Colorimetric Broth Microdilution Method. J Clin Microbiol. 2017 jun;55(6):1883-1893. Doi: https://doi.org/10.1128/JCM.00338-17.
22- Sharma A, Rabha D, Ahmed G. In vitro antifungal susceptibility of Malassezia isolates from pityriasis versicolor lesions. Indiano J Dermatol Venereol Leprol. 2017 Mar-Apr;83(2):249-251. Doi: https://doi.org/10.4103/0378-6323.193617.
23- Iatta R, Imediato D, Montagna MT, Otranto D, Cafarchia C. In vitro antifungal susceptibility of Malassezia furfur from bloodstream infections. Med Mycol. 2015 abr;53(3):269-274. Doi: https://doi.org/10.1093/mmy/myu089.
24- Carrillo-Muñoz AJ, Rojas M, Tur-Tur C, Los Angeles Sosa H, Diez GO, Espada CM, Payá MJ et al. In vitro antifungal activity of topical and systemic antifungal drugs against Malassezia species. Micoses. Sept 2013;56(5):571-5. Doi: https://doi.org/10.1111/myc.12076.
25- Miranda KC, Araújo CR, Costa CR, Passos XS, Fernandes OFL, Silva MRR. Antifungal activities of azole agents against the Malassezia species. Int J Antimicrob Agents [Internet]. Mar 2007[cited 2018 May 29];29(3):281-4. Avaliable from: https://linkinghub.elsevier.com/retrieve/pii/S0924-8579(06)00431-6.
26- Rincón S, Cepero de García MC, Espinel-Ingroff A. A Modified Christensen's Urea and CLSI Broth Microdilution Method for Testing Susceptibilities of Six Malassezia Species to Voriconazole, Itraconazole, and Ketoconazole. J Clin Microbiol [Internet]. 2006 sept [cited 2018 May 29]; 44 (9): 3429-31. Avaliable from: http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=16954293.
27- Clinical and Laboratory Standards Institute (CLSI). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard—Third Edition. CLSI document M27-A3 (ISBN 1-56238-666-2). Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2008. Available from: http://star.sstir.cn/upload/attach/attach20090828093456pyyz6w48nl.pdf.
28- Oliveri S, Trovato G, Betta P, and Romeo MG, Nicoletti L. Malassezia furfur fungaemia in a neonatal patient detected by lysis-centrifugation blood culture method: first case reported in Italy. Mycoses. 2011 sep;54(5):e638-40. Doi: https://doi.org/10.1111/j.1439-0507.2010.01955.x.
2- Theelen B, Carfacharia C, Gaitanis G, Bassukas ID, Boekhout T, Dawson TL. Malassezia ecology, pathophysiology, and treatment. Med mycol [internet]. 2018 apr [cited 2018 mai 30];56:S10–S25. Available from: https://academic.oup.com/mmy/issue/56/suppl_1.
3- Wu G, Zhao H, Li C, Rajapakse MP, Wong WC, J Xu J, et al. Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin. Plos Genetics. 2015 nov;11(11):e1005614. https://doi.org/10.1371/journal.pgen.1005614.
4- Cabañes FJ. Malassezia Yeasts: How Many Species Infect Humans and Animals? PLoS Pathog. 2014 feb;10(2):e1003892. Doi: http://doi.org/10.1371/journal.ppat.1003892
5- Kistowska M, Fenini G, Jankovic D, Feldmeyer L, Kerl K, Bosshard P. Malassezia yeasts activate the NLRP3 inflammasome in antigen-presenting cells via Syk-kinase signalling. Exp dermatol. 2014 dec;23(12):884–889. Doi: https://doi.org/10.1111/exd.12552
6- Velegraki A, Cafarchia C, Gaitanis G, Iatta R, Boekhout T. Malassezia Infections in Humans and Animals: Pathophysiology, Detection, and Treatment. PLoS Pathog. 2015 jan;11 (1):e1004523. Doi: https://doi.org/10.1371/journal.ppat.1004523
7- Gaitanis G, Velegraki A, Magiatis P, Pappas P, Bassukas ID. Could Malassezia yeasts be implicated in skin carcinogenesis through the production of aryl-hydrocarbon receptor ligands? Hipóteses Med [internet]. 2011 jul [cited 2018 mar 25];77(1):47-51. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0306-9877(11)00122-8.
8- Hald M, Maiken AC, Else SL, Rune L, Erik FK, Saunte, DML. Evidence-based Danish Guidelines for the Treatment of Malassezia-related Skin Diseases. Acta Derm Venereol [Internet]. 2015 jan [cited 2018 mai 30];95(1):12-9. Available from: https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-1825.
9- Lorch JM, Palmer JM, Vanderwolf KJ, Schmidt KZ, Verant ML, Weller TJ, Blehert DS. Malassezia vespertilionis sp. nov.: a new cold-tolerant species of yeast isolated from bats. Persoonia [internet]. 2018 feb [cited 2018 mar 30];41:56–70. Available from: http://repository.naturalis.nl/document/654583.
10- Thayikkannu AB, Kindo AJ, Veeraraghavan M. Fungal prophylaxis in neonates: a review article. Adv neonatal care [Internet]. 2014 feb [cited 2017 dec 31];14(1):17-23. Available from: http://www-periodicos-capes-gov-br.ez9.periodicos.capes.gov.br/.
11- Ruiz LS, Pereira VBR. Importância dos fungos no ambiente hospitalar. Bol Inst Adolfo Lutz [Internet]. 2016 jan-dez [cited 2018 mar 30];2016 26(U): art.2. Available from: http://www.ial.sp.gov.br/resources/insituto-adolfolutz/publicacoes/bial/bial_26/26u_art-2.pdf.
12- Mendes KDS, Silveira RCCP, Galvão CM. Revisão integrativa: método de pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & contexto enferm [Internet]. 2008 dec [cited 2018 May 29];17(4):758-764. Available from: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-07072008000400018&lng=en
13- Ercole FF, Melo LS, Alcoforado CLGC. Integrative Review versus Systematic Review. Rev Min Enferm [Internet]. 2014 jan/mar [cited 2018 May 29];18(1):1-260. Available from: http://www.reme.org.br/artigo/detalhes/904
14- Silva DP, Nunes JBB, Moreira RTF, Costa LC. Primeiros socorros: objeto de educação em saúde para professors. Rev enferm UFPE on line [Internet]. 2018 mai [cited 2018 May 29];12(5):1444-53. Available from: https://periodicos.ufpe.br/revistas/revistaenfermagem/article/viewFile/234592/28912.
15- Souza MT, Silva MD, Carvalho R. Integrative review: what is it? How to do it? Einstein [Internet]. 2010 jan [cited 2018 May 29]8(11):102-6. Available from: http://www.scielo.br/pdf/eins/v8n1/1679-4508-eins-8-1-0102.pdf.
16- Galvis-Marína JC, Rodríguez-Bocanegraa MX, Pulido-Villa AP, Castañeda-Salazara MR, Celis-Ramírezb AM, Linares-Linares MY. Actividad antifúngica in vitro de azoles y anfotericina B frente a Malassezia furfur por el método de microdilución M27-A3 del CLSI y Etest®. Rer iberoam micol [Internet]. 2017 april–june [cited 2018 May 29];34:89-93. Available from: https://www.sciencedirect.com/science/article/pii/S1130140616300560.
17- Al-Sweih N, Ahmad S, Joseph L, Khan S, Khan Z. Malassezia pachydermatis fungemia in a preterm neonate resistant to fluconazole and flucytosine. Med Mycol Case Rep [Internet]. 2014 mai [cited 2018 May 29];5:9-11. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24936403.
18- Rojas FD, Sosa MDLA, Fernández MS, Cattana ME, Córdoba SB, Giusiano GE. Antifungal susceptibility of Malassezia furfur, Malassezia sympodialis, and Malassezia globosa to azole drugs and amphotericin B evaluated using a broth microdilution method. Sabouraudia [Internet]. 2014 aug [cited 2018 May 29];52(6), 641-646. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24965946.
19- Iatta R, Immediato D, Montagna MT, Otranto D, Cafarchia C. In vitro activity of two amphotericin B formulations against Malassezia furfur strains recovered from patients with bloodstream infections. Med Mycol [Internet]. 2015 apr [cited 2018 May 31];53(3):269-74. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25631480.
20- Rojas FD, Córdoba SN, Sosa MLA, Zalazar LC, Fernández MS, Cattana ME. Antifungal susceptibility testing of Malassezia yeast: comparison of two different methodologies. Mycosis. 2016 sept;60(2):104-111. Doi: https://doi.org/10.1111/myc.12556.
21- Leong C, Buttafuoco U, Glatz H, Bosshard PP. Antifungal Susceptibility Testing of Malassezia spp. with an Optimized Colorimetric Broth Microdilution Method. J Clin Microbiol. 2017 jun;55(6):1883-1893. Doi: https://doi.org/10.1128/JCM.00338-17.
22- Sharma A, Rabha D, Ahmed G. In vitro antifungal susceptibility of Malassezia isolates from pityriasis versicolor lesions. Indiano J Dermatol Venereol Leprol. 2017 Mar-Apr;83(2):249-251. Doi: https://doi.org/10.4103/0378-6323.193617.
23- Iatta R, Imediato D, Montagna MT, Otranto D, Cafarchia C. In vitro antifungal susceptibility of Malassezia furfur from bloodstream infections. Med Mycol. 2015 abr;53(3):269-274. Doi: https://doi.org/10.1093/mmy/myu089.
24- Carrillo-Muñoz AJ, Rojas M, Tur-Tur C, Los Angeles Sosa H, Diez GO, Espada CM, Payá MJ et al. In vitro antifungal activity of topical and systemic antifungal drugs against Malassezia species. Micoses. Sept 2013;56(5):571-5. Doi: https://doi.org/10.1111/myc.12076.
25- Miranda KC, Araújo CR, Costa CR, Passos XS, Fernandes OFL, Silva MRR. Antifungal activities of azole agents against the Malassezia species. Int J Antimicrob Agents [Internet]. Mar 2007[cited 2018 May 29];29(3):281-4. Avaliable from: https://linkinghub.elsevier.com/retrieve/pii/S0924-8579(06)00431-6.
26- Rincón S, Cepero de García MC, Espinel-Ingroff A. A Modified Christensen's Urea and CLSI Broth Microdilution Method for Testing Susceptibilities of Six Malassezia Species to Voriconazole, Itraconazole, and Ketoconazole. J Clin Microbiol [Internet]. 2006 sept [cited 2018 May 29]; 44 (9): 3429-31. Avaliable from: http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=16954293.
27- Clinical and Laboratory Standards Institute (CLSI). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standard—Third Edition. CLSI document M27-A3 (ISBN 1-56238-666-2). Clinical and Laboratory Standards Institute, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 USA, 2008. Available from: http://star.sstir.cn/upload/attach/attach20090828093456pyyz6w48nl.pdf.
28- Oliveri S, Trovato G, Betta P, and Romeo MG, Nicoletti L. Malassezia furfur fungaemia in a neonatal patient detected by lysis-centrifugation blood culture method: first case reported in Italy. Mycoses. 2011 sep;54(5):e638-40. Doi: https://doi.org/10.1111/j.1439-0507.2010.01955.x.
Publicado
03-05-2020
Como Citar
Silva, D. P. da ., Lessa, I. L. P. ., Silva, D. N. de O. ., Dâmaso, R. de C. B. A. ., & Moreira, R. T. de F. . (2020). SUSCETIBILIDADE ANTIFÚNGICA DE LEVEDURAS DO GÊNERO Malassezia. Revista Renome, 8(1), 01–09. Recuperado de https://www.periodicos.unimontes.br/index.php/renome/article/view/2251
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